Alpha-GPC may increase the expression of Nerve Growth Factor receptors in the rat cerebellar cortex.
CONCLUSION: These results suggest that choline alfoscerate treatment may increase the expression of NGF receptors in the rat cerebellar cortex."
Alpha-GPC reverses scopolamine-induced amnesia and improves learning in young and old rats.
Abstract Title: Molecular mechanisms mediating the effects of L-alpha-glycerylphosphorylcholine, a new cognition- enhancing drug, on behavioural and biochemical parameters in young and aged rats.
Abstract Source: Pharmacol Biochem Behav. 1992 Sep;43(1):139--51. NCBI Public Medical Research PMID: 1409797
Abstract Author(s): G Schettini, C Ventra, T Florio, M Grimaldi, O Meucci, A Scorziello, A Postiglione, A Marino
CONCLUSION: These results show that alpha-GPC improves the performance of animals in both active and passive conditioning tasks. Furthermore, subchronic treatment with the compound enhances in young and restores in aged animals the transduction of the signal, namely, the receptor- mediated production of inositol phosphate and the potassium-induced calcium mobilization. These modifications may represent at least part of the molecular mechanism of action of the compound."
Article Published Date: Sep 01, 1992